Health-Related Quality of Life in Cystinuria Patients
BAUS ePoster online library. Shahrjerdi P. 06/25/19; 259475; P11-10
Ms. Puneh Shahrjerdi
Ms. Puneh Shahrjerdi
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Abstract
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Cystinuric patients typically suffer frequent episodes of renal colic causing disruption to normal life. The health-related quality of life (HRQOL) in a cystinuric population from a single centre was assessed using the validated Wisconsin Stone Quality of Life Questionnaire (WISQOL).
An online version of the WISQOL was created and cystinuria patients asked to complete it electronically. Additional health questions were asked to stratify patients. Validity of the online questionnaire was tested using Cronbach's Alpha. To act as a comparison group, recurrent non-cystine stone formers attending our stone clinic also completed the online questionnaire.
75 cystinuric patients completed the questionnaire in a 4-week timeframe. Internal consistency of the questionnaire was high (Cronbach's α = 0.82). Female patients, those with current stones, recent symptoms and those who had visited the emergency department within four weeks prior to the questionnaire had significantly lower (worse) overall HRQOL scores(p<0.05). There was no significant difference in overall HRQOL in cystinuria patients for the following subgroups: family history of kidney stones; hospitalisation in previous four weeks, taking stone preventative medications, altered diet and fluid intake due to stone formation(p>0.05). Cystinuric patients did not have significantly different mean overall or subscale scores compared to 35 non-cystinuria stone forming patients(p>0.05).
This study challenges the notion that male stone patients have worse HRQOL, at least in cystinuria. As expected, patients with current stones or symptoms had lower HRQOL. In previous American studies, cystine stone formers had lower HRQOL compared to non-cystine, however this was not replicated in our UK population.
Cystinuric patients typically suffer frequent episodes of renal colic causing disruption to normal life. The health-related quality of life (HRQOL) in a cystinuric population from a single centre was assessed using the validated Wisconsin Stone Quality of Life Questionnaire (WISQOL).
An online version of the WISQOL was created and cystinuria patients asked to complete it electronically. Additional health questions were asked to stratify patients. Validity of the online questionnaire was tested using Cronbach's Alpha. To act as a comparison group, recurrent non-cystine stone formers attending our stone clinic also completed the online questionnaire.
75 cystinuric patients completed the questionnaire in a 4-week timeframe. Internal consistency of the questionnaire was high (Cronbach's α = 0.82). Female patients, those with current stones, recent symptoms and those who had visited the emergency department within four weeks prior to the questionnaire had significantly lower (worse) overall HRQOL scores(p<0.05). There was no significant difference in overall HRQOL in cystinuria patients for the following subgroups: family history of kidney stones; hospitalisation in previous four weeks, taking stone preventative medications, altered diet and fluid intake due to stone formation(p>0.05). Cystinuric patients did not have significantly different mean overall or subscale scores compared to 35 non-cystinuria stone forming patients(p>0.05).
This study challenges the notion that male stone patients have worse HRQOL, at least in cystinuria. As expected, patients with current stones or symptoms had lower HRQOL. In previous American studies, cystine stone formers had lower HRQOL compared to non-cystine, however this was not replicated in our UK population.
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