Emergency sperm and spermatogonial stem cell retrieval in oncological context
BAUS ePoster online library. Micol L. 11/10/20; 304244; P6-13
Lionel Micol
Lionel Micol
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Emergency sperm and spermatogonial stem cell retrieval in oncological context

Micol L1, Adenubi F1, Lane S2, Williamson E1, Sangster P1
1UCLH, London, United Kingdom, 2Oxford University Hospitals, United Kingdom

Background:
Patients receiving chemotherapy or bone marrow transplant in oncological or haematological context are at high risk of losing their fertility hence the recommendation for sperm cryopreservation from semen. However, patients presenting with either azoospermia or inability to provide semen, face the risk to have to sacrifice their possibility to father their biological children. To those patients our andrology unit aims at offering timely preservation of their fertility by surgical sperm/stem cell retrieval.

Methods:
Patients were enrolled prospectively and data analysed retrospectively.

Results:
We screen on annual basis about 500 patients necessitating chemotherapy or bone marrow transplant,of which 10.5% present with azoospermia. From January 2018 to September 2019, 40 patients (median age of 18.4 years old and average testosterone at 7.1 nmol/L) underwent surgical sperm/stem cell retrieval which could be offered within one week from semen-analysis and preceding one day from chemotherapy start date (medians expressed). Primary diagnoses were sarcoma in 11, leukaemia in 1, lymphoma in 10, testicular tumour in 5, multiple myeloma in 1, prostate cancer in 1, while 3 patients had non-oncological haematological diseases.
14 patients underwent TeSE, 5 had oncoTeSE, 5 had electroejaculation and TeSE, 1 had TeSA and 15 had spermatogonial stem cell retrieval. The success rate for surgical sperm retrieval was 78.9% to which could be added the 13 patients who had spermatogonial stem cell retrieval. Average Johnsen score was 5.08.

Conclusion:
Emergency sperm/stem cell retrieval in oncological context is a valid treatment option with high success rate for patients unable to cryopreservation semen.
Emergency sperm and spermatogonial stem cell retrieval in oncological context

Micol L1, Adenubi F1, Lane S2, Williamson E1, Sangster P1
1UCLH, London, United Kingdom, 2Oxford University Hospitals, United Kingdom

Background:
Patients receiving chemotherapy or bone marrow transplant in oncological or haematological context are at high risk of losing their fertility hence the recommendation for sperm cryopreservation from semen. However, patients presenting with either azoospermia or inability to provide semen, face the risk to have to sacrifice their possibility to father their biological children. To those patients our andrology unit aims at offering timely preservation of their fertility by surgical sperm/stem cell retrieval.

Methods:
Patients were enrolled prospectively and data analysed retrospectively.

Results:
We screen on annual basis about 500 patients necessitating chemotherapy or bone marrow transplant,of which 10.5% present with azoospermia. From January 2018 to September 2019, 40 patients (median age of 18.4 years old and average testosterone at 7.1 nmol/L) underwent surgical sperm/stem cell retrieval which could be offered within one week from semen-analysis and preceding one day from chemotherapy start date (medians expressed). Primary diagnoses were sarcoma in 11, leukaemia in 1, lymphoma in 10, testicular tumour in 5, multiple myeloma in 1, prostate cancer in 1, while 3 patients had non-oncological haematological diseases.
14 patients underwent TeSE, 5 had oncoTeSE, 5 had electroejaculation and TeSE, 1 had TeSA and 15 had spermatogonial stem cell retrieval. The success rate for surgical sperm retrieval was 78.9% to which could be added the 13 patients who had spermatogonial stem cell retrieval. Average Johnsen score was 5.08.

Conclusion:
Emergency sperm/stem cell retrieval in oncological context is a valid treatment option with high success rate for patients unable to cryopreservation semen.
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