Growth and renal function of renal oncocytomas on active surveillance
BAUS ePoster online library. Neves J. 06/23/21; 319035; p12-7
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Joana Neves
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Abstract
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Introduction: We aimed to study the natural history of renal oncocytomas and determine how growth associates with renal function over time, and disease-specific survival.
Patients and methods: Retrospective cohort of consecutive patients with renal oncocytoma on active surveillance reviewed at a large volume UK tertiary referral centre (2012 to 2019). Comparison between groups was tested using the Mann-Whitney U and the Chi-square tests. A mixed-effects model with a random intercept for patient was used to study the longitudinal association between tumour size and estimated glomerular filtration rate (eGFR).
Results: Data from 99 patients with 102 lesions was analysed. Most patients were male (70.7%), median age was 69 years (IQR 13). The median follow-up was 29 months (IQR 26). Most lesions were small renal masses, 23.5% measured over 4 cm. Over half (64.7%) grew at a median rate of 3 mm per year (IQR 4). No association was observed between tumour size and eGFR over time (p=0.871). Ten lesions (9.8%) were subsequently treated. Two deaths were reported, none related to the diagnosis of renal oncocytoma.
Conclusions: Natural history data from the largest active surveillance cohort of renal oncocytomas to date show that renal function is not negatively impacted by growing oncocytomas. Clinical outcomes are excellent after a median follow up of over 2 years.
Patients and methods: Retrospective cohort of consecutive patients with renal oncocytoma on active surveillance reviewed at a large volume UK tertiary referral centre (2012 to 2019). Comparison between groups was tested using the Mann-Whitney U and the Chi-square tests. A mixed-effects model with a random intercept for patient was used to study the longitudinal association between tumour size and estimated glomerular filtration rate (eGFR).
Results: Data from 99 patients with 102 lesions was analysed. Most patients were male (70.7%), median age was 69 years (IQR 13). The median follow-up was 29 months (IQR 26). Most lesions were small renal masses, 23.5% measured over 4 cm. Over half (64.7%) grew at a median rate of 3 mm per year (IQR 4). No association was observed between tumour size and eGFR over time (p=0.871). Ten lesions (9.8%) were subsequently treated. Two deaths were reported, none related to the diagnosis of renal oncocytoma.
Conclusions: Natural history data from the largest active surveillance cohort of renal oncocytomas to date show that renal function is not negatively impacted by growing oncocytomas. Clinical outcomes are excellent after a median follow up of over 2 years.
Introduction: We aimed to study the natural history of renal oncocytomas and determine how growth associates with renal function over time, and disease-specific survival.
Patients and methods: Retrospective cohort of consecutive patients with renal oncocytoma on active surveillance reviewed at a large volume UK tertiary referral centre (2012 to 2019). Comparison between groups was tested using the Mann-Whitney U and the Chi-square tests. A mixed-effects model with a random intercept for patient was used to study the longitudinal association between tumour size and estimated glomerular filtration rate (eGFR).
Results: Data from 99 patients with 102 lesions was analysed. Most patients were male (70.7%), median age was 69 years (IQR 13). The median follow-up was 29 months (IQR 26). Most lesions were small renal masses, 23.5% measured over 4 cm. Over half (64.7%) grew at a median rate of 3 mm per year (IQR 4). No association was observed between tumour size and eGFR over time (p=0.871). Ten lesions (9.8%) were subsequently treated. Two deaths were reported, none related to the diagnosis of renal oncocytoma.
Conclusions: Natural history data from the largest active surveillance cohort of renal oncocytomas to date show that renal function is not negatively impacted by growing oncocytomas. Clinical outcomes are excellent after a median follow up of over 2 years.
Patients and methods: Retrospective cohort of consecutive patients with renal oncocytoma on active surveillance reviewed at a large volume UK tertiary referral centre (2012 to 2019). Comparison between groups was tested using the Mann-Whitney U and the Chi-square tests. A mixed-effects model with a random intercept for patient was used to study the longitudinal association between tumour size and estimated glomerular filtration rate (eGFR).
Results: Data from 99 patients with 102 lesions was analysed. Most patients were male (70.7%), median age was 69 years (IQR 13). The median follow-up was 29 months (IQR 26). Most lesions were small renal masses, 23.5% measured over 4 cm. Over half (64.7%) grew at a median rate of 3 mm per year (IQR 4). No association was observed between tumour size and eGFR over time (p=0.871). Ten lesions (9.8%) were subsequently treated. Two deaths were reported, none related to the diagnosis of renal oncocytoma.
Conclusions: Natural history data from the largest active surveillance cohort of renal oncocytomas to date show that renal function is not negatively impacted by growing oncocytomas. Clinical outcomes are excellent after a median follow up of over 2 years.
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