Long term outcomes of Dynamic Sentinel Lymph Node Biopsy (DSNB) for clinically impalpable (cN0) penile cancer patients- an eUROGEN study
BAUS ePoster online library. Schifano N. 06/21/21; 319083; p4-5
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Nicolo Schifano
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Abstract
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INTRODUCTION: We aimed to assess the diagnostic accuracy of DSNB, cancer specific survival (CSS) and recurrence free survival after positive DSNB.
MATERIALS: An eUROGEN retrospective study of 509 penile cancer patients undergoing DSNB. Age, type of primary surgery, complications after DSNB, tumour stage, tumour grade were all reported. False negative was defined as inguinal lymph node recurrence within 12 months from a previous negative DSNB. Sensitivity and specificity of DSNB were calculated. Kaplan-Meier analysis estimated the 5-years CSS and recurrence free-survival rates among patients with positive DNSB and RLND.
RESULTS: 509 patients with cN0 penile cancer were identified. Median follow-up for local recurrence and CSS were 62.5 months (IQR 28.5-91) and 63.5 months (IQR 26.5-90) respectively. 993 groins were studied. 37 patients had positive histology at DSNB. 37 patients underwent further RLND with 34 of them having positive histology at RLND. At DSNB true positives were 37 (7.27%), false negatives 3 (0.59). Sensitivity and specificity were 92.5% and 100% respectively. Multivariable Cox regression analysis identified positive LN histology both at DSNB and at RLND as predictors for reduced CSS (HR 4.59, CI: 2.35-8.95, p<0.0001) and (HR 5.64, p = 0.0004). Positive LN histology at DSNB and RLND was a predictor for reduced recurrence free survival HR 4.04 and HR 6.98 all p<0.0001. The 5-years CSS for positive LN histology at DSNB/RLND were 69.7% and 69.6% respectively.
CONCLUSIONS: DSNB shows a sensitivity of 92.5%. Positive histology after DSNB is a predictor of reduced CSS and recurrence free survival.
MATERIALS: An eUROGEN retrospective study of 509 penile cancer patients undergoing DSNB. Age, type of primary surgery, complications after DSNB, tumour stage, tumour grade were all reported. False negative was defined as inguinal lymph node recurrence within 12 months from a previous negative DSNB. Sensitivity and specificity of DSNB were calculated. Kaplan-Meier analysis estimated the 5-years CSS and recurrence free-survival rates among patients with positive DNSB and RLND.
RESULTS: 509 patients with cN0 penile cancer were identified. Median follow-up for local recurrence and CSS were 62.5 months (IQR 28.5-91) and 63.5 months (IQR 26.5-90) respectively. 993 groins were studied. 37 patients had positive histology at DSNB. 37 patients underwent further RLND with 34 of them having positive histology at RLND. At DSNB true positives were 37 (7.27%), false negatives 3 (0.59). Sensitivity and specificity were 92.5% and 100% respectively. Multivariable Cox regression analysis identified positive LN histology both at DSNB and at RLND as predictors for reduced CSS (HR 4.59, CI: 2.35-8.95, p<0.0001) and (HR 5.64, p = 0.0004). Positive LN histology at DSNB and RLND was a predictor for reduced recurrence free survival HR 4.04 and HR 6.98 all p<0.0001. The 5-years CSS for positive LN histology at DSNB/RLND were 69.7% and 69.6% respectively.
CONCLUSIONS: DSNB shows a sensitivity of 92.5%. Positive histology after DSNB is a predictor of reduced CSS and recurrence free survival.
INTRODUCTION: We aimed to assess the diagnostic accuracy of DSNB, cancer specific survival (CSS) and recurrence free survival after positive DSNB.
MATERIALS: An eUROGEN retrospective study of 509 penile cancer patients undergoing DSNB. Age, type of primary surgery, complications after DSNB, tumour stage, tumour grade were all reported. False negative was defined as inguinal lymph node recurrence within 12 months from a previous negative DSNB. Sensitivity and specificity of DSNB were calculated. Kaplan-Meier analysis estimated the 5-years CSS and recurrence free-survival rates among patients with positive DNSB and RLND.
RESULTS: 509 patients with cN0 penile cancer were identified. Median follow-up for local recurrence and CSS were 62.5 months (IQR 28.5-91) and 63.5 months (IQR 26.5-90) respectively. 993 groins were studied. 37 patients had positive histology at DSNB. 37 patients underwent further RLND with 34 of them having positive histology at RLND. At DSNB true positives were 37 (7.27%), false negatives 3 (0.59). Sensitivity and specificity were 92.5% and 100% respectively. Multivariable Cox regression analysis identified positive LN histology both at DSNB and at RLND as predictors for reduced CSS (HR 4.59, CI: 2.35-8.95, p<0.0001) and (HR 5.64, p = 0.0004). Positive LN histology at DSNB and RLND was a predictor for reduced recurrence free survival HR 4.04 and HR 6.98 all p<0.0001. The 5-years CSS for positive LN histology at DSNB/RLND were 69.7% and 69.6% respectively.
CONCLUSIONS: DSNB shows a sensitivity of 92.5%. Positive histology after DSNB is a predictor of reduced CSS and recurrence free survival.
MATERIALS: An eUROGEN retrospective study of 509 penile cancer patients undergoing DSNB. Age, type of primary surgery, complications after DSNB, tumour stage, tumour grade were all reported. False negative was defined as inguinal lymph node recurrence within 12 months from a previous negative DSNB. Sensitivity and specificity of DSNB were calculated. Kaplan-Meier analysis estimated the 5-years CSS and recurrence free-survival rates among patients with positive DNSB and RLND.
RESULTS: 509 patients with cN0 penile cancer were identified. Median follow-up for local recurrence and CSS were 62.5 months (IQR 28.5-91) and 63.5 months (IQR 26.5-90) respectively. 993 groins were studied. 37 patients had positive histology at DSNB. 37 patients underwent further RLND with 34 of them having positive histology at RLND. At DSNB true positives were 37 (7.27%), false negatives 3 (0.59). Sensitivity and specificity were 92.5% and 100% respectively. Multivariable Cox regression analysis identified positive LN histology both at DSNB and at RLND as predictors for reduced CSS (HR 4.59, CI: 2.35-8.95, p<0.0001) and (HR 5.64, p = 0.0004). Positive LN histology at DSNB and RLND was a predictor for reduced recurrence free survival HR 4.04 and HR 6.98 all p<0.0001. The 5-years CSS for positive LN histology at DSNB/RLND were 69.7% and 69.6% respectively.
CONCLUSIONS: DSNB shows a sensitivity of 92.5%. Positive histology after DSNB is a predictor of reduced CSS and recurrence free survival.
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